The South Sydney project: interaction and archive aesthetics

This practice-based thesis questions how interactive media artworks affect the way audiences engage with the past. It considers contemporary art’s ‘impulse’ towards archives within the context of the age of Big Data. At a time when society is generating more information than ever before, this thesis explores how artists working with interactive databases can contribute novel systems and aesthetic experiences in order to carve new ways into and through archives. This thesis brings into dialogue practical and theoretical discoveries made along the journey of reimagining an oral history archive through the system of an immersive responsive installation. It argues that interactive artworks can allow for an embodied, exploratory and generative engagement with archival material. Further, it suggests that such processual and emergent accounts of the past are appropriate ways of modelling the world and its archived traces in a digital era characterised by swathes of stored data and fluctuating information flows. As critically interdisciplinary work across the fields of new media art and history, this research also suggests the value of such experimental methodologies for rethinking traditional approaches to archives with a view to generating aesthetic and affective, rather than factual and textual, engagements with the past

Assessment of a causal relationship between body mass index and atopic dermatitis

This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.A.B-A. is funded by a grant awarded to L.P. by the British Skin Foundation (8010 Innovative Project). A.B-A, L.P., S.W., and G.D.S. work in a research unit funded by the UK Medical Research Council (MC_UU_00011/1). B.B., M.L., L.G.F., and B.O.A. work in a research unit funded by Stiftelsen Kristian Gerhard Jebsen, Faculty of Medicine and Health Sciences, NTNU; The Liaison Committee for Education, Research, and Innovation in Central Norway; and the Joint Research Committee between St. Olav's Hospital and the Faculty of Medicine and Health Sciences, NTNU. J.T. is supported by an Academy of Medical Sciences Springboard award, which is supported by the Academy of Medical Sciences, the Wellcome Trust, GCRF, the Government Department of Business, Energy and Industrial strategy, the British Heart Foundation, and Diabetes UK. E.H.M. was supported by a research grant from the Liaison Committee for Education, Research and Innovation in Central Norway. G.A.V. is supported by a research grant from the Norwegian Research Council (grant 250335). M.L. is supported by research grants from the Liaison Committee for Education, Research and Innovation in Central Norway. J.B.N. was supported by grants from the Danish Heart Foundation and the Lundbeck Foundation. L.P. is supported by an Academy of Medical Sciences Springboard Award, which is supported by the Wellcome Trust, the Government Department for Business, Energy and Industrial Strategy, the Global Challenges Research Fund, and the British Heart Foundation [SBF003/1094]. S.J.B. holds a Wellcome Trust Senior Research Fellowship in Clinical Science (106865/Z/15/Z) and a British Skin Foundation large project grant. The genotyping in HUNT was financed by the National Institutes of Health; the University of Michigan; the Research Council of Norway; the Liaison Committee for Education, Research, and Innovation in Central Norway; and the Joint Research Committee between St. Olav's Hospital and the Faculty of Medicine and Health Sciences, NTNU. The funders had no influence on study design, data collection and analysis, decision to publish, or preparation of the article. Disclosure of potential conflict of interest: L. Paternoster has received personal fees from Merck for Scientific Input Engagement related to MR methodology. The rest of the authors declare that they have no relevant conflicts of interest.published version, accepted version (12 month embargo), submitted versio

“Collecting spring water reminds us how to be human”: in search of an ethic of care for the springs of southern Cape Town

Between 2015 and 2018 Cape Town was affected by a drought more severe than any on record. When it became clear that Cape Town might actually run out of water, thousands of its citizens flocked to the historical springs that flow from Table Mountain's groundwater, which for many of whom it was their first time collecting spring water. However, at the height of the water crisis, the municipality cemented over one of these vital springs after numerous complaints of disturbance by residents. Piped to a newly constructed water collection site enclosed by fences a kilometer away, the water was made accessible to the public through 16 industrial taps. While this action from the municipality may have been the only viable solution, it was experienced as a huge loss to the people of Cape Town. This study investigates why the design of the current spring water collection point became the source of such criticism. It compares the re-designed site with two of Cape Town's southern springs that still flow freely, investigating the meaning and influence of unrestricted flowing spring water through public engagement on site, asking what draws people to collect spring water. Key themes that emerged include health and wellbeing; and connection with other humans, with history, with nature and with a greater spirit. Springs are powerful agents for an ethic of care, the study finds, and water a powerful medium of connection. Yet, the city's water policies are shaped by the kind of thinking that sees water only as a commodity, reflected in an urban design that further alienates people from water and nature. In this era of the Anthropocene, itself a condition of this alienation of people from the earth, the paper concludes and proposes biophilic design principles that foster the sensibilities of connection and interdependence as a vital part of urban design for a shared future where people come to know what it means to be human as participants within a living world

The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome.

Journal Article"This is the peer reviewed version of the following article: Lasers in Surgery and Medicine 42:613–619 (2010), which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/lsm.20943/pdf. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."BACKGROUND AND OBJECTIVE: The relationship between protoporphyrin IX (PpIX) photobleaching and cellular damage during aminolevulinic (ALA) photodynamic therapy (PDT) has been studied at the cellular level. This study assessed the capability of a non-invasive fluorescence imaging system (Dyaderm, Biocam, Germany), to monitor changes in PpIX during real time methyl-aminolevulinate (MAL) PDT in dermatological lesions, and thus to act as a predictive tool in terms of observed clinical outcome post-treatment. MATERIALS AND METHODS: Patients attending Royal Cornwall Hospital (Truro, UK) for MAL-PDT to licensed lesions (actinic keratosis, Bowen's disease, and basal cell carcinoma) were monitored using the pre-validated non-invasive fluorescence imaging system. Patients were imaged at three distinct time points: prior to the application of MAL, after the 3 hours of MAL application and immediately following light irradiation. The fluorescence intensity of the images were analysed with image analysis software and the percentage change in fluorescence during light irradiation was related to the clinical outcome observed 3 months following treatment. In total 100 patients underwent at least one session of MAL-PDT. RESULTS: Significantly higher levels of change in PpIX fluorescence during light irradiation (P0.500) was observed in the total levels of PpIX recorded after MAL application in patients undergoing partial and complete clearance at 3 months. CONCLUSIONS: PpIX photobleaching is indicative of the level of cellular damage PDT treatment will induce and therefore the clinical outcome expected within patients. This study indicated the potential of the commercially available fluorescence imaging system investigated to predict treatment success at the time of light irradiation and in the future it may be possible to employ it to individualise treatment parameters to improve dermatological PDT efficacy/outcome

Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification

Author's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives LicenseBACKGROUND: Dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) is utilized to successfully treat dermatological conditions. This study monitored fluorescence changes attributed to the accumulation and destruction of the photosensitizer, protoporphyrin IX (PpIX), at several different stages during the first and second treatments of clinical dermatological MAL-PDT. METHODS: A commercially available, non-invasive, fluorescence imaging system (Dyaderm, Biocam, Germany) was utilized to monitor fluorescence changes during the first and second MAL-PDT treatments in seventy-five lesions. RESULTS: The clinical data indicated statistically significant increases in fluorescence within lesions following the application of MAL for both treatments (P<0.001 and P<0.01 respectively) and subsequent statistically significant decreases in fluorescence within the lesions following light irradiation for both treatments (P<0.001 and P<0.01 respectively) whilst normal skin fluorescence remained unaltered. Lesions receiving a second treatment accumulated and dissipated significantly less PpIX (P<0.05) than during the first treatment. No significant differences were noted in PpIX accumulation or dissipation during MAL-PDT when gender, age, lesion type and lesion surface area were considered. CONCLUSIONS: It can therefore be concluded that PpIX fluorescence imaging can be used in real-time to assess PpIX levels during dermatological PDT. Similar observations were recorded from the three currently licensed indications indicating that the standard 'one size fits all' protocol currently employed appears to allow adequate PpIX accumulation, which is subsequently fully utilized during light irradiation regardless of patient age, gender or lesion surface area

\u3cem\u3eEscherichia coli\u3c/em\u3e Pathotypes Occupy Distinct Niches in the Mouse Intestine

Since the first step of the infection process is colonization of the host, it is important to understand how Escherichia coli pathogens successfully colonize the intestine. We previously showed that enterohemorrhagic O157:H7 strain E. coli EDL933 colonizes a niche in the streptomycin-treated mouse intestine that is distinct from that of human commensal strains, which explains how E. coli EDL933 overcomes colonization resistance imparted by some, but not all, commensal E. coli strains. Here we sought to determine if other E. coli pathogens use a similar strategy. We found that uropathogenic E. coli CFT073 and enteropathogenic E. coli E2348/69 occupy intestinal niches that are distinct from that of E. coli EDL933. In contrast, two enterohemorrhagic strains, E. coli EDL933 and E. coli Sakai, occupy the same niche, suggesting that strategies to prevent colonization by a given pathotype should be effective against other strains of the same pathotype. However, we found that a combination of commensal E. coli strains that can prevent colonization by E. coli EDL933 did not prevent colonization by E. coli CFT073 or E. coli E2348/69. Our results indicate that development of probiotics to target multiple E. coli pathotypes will be problematic, as the factors that govern niche occupation and hence stable colonization vary significantly among strains

Parental diabetes and birthweight in 236 030 individuals in the UK biobank study

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: The UK Biobank study provides a unique opportunity to study the causes and consequences of disease. We aimed to use the UK Biobank data to study the well-established, but poorly understood, association between low birthweight and type 2 diabetes. METHODS: We used logistic regression to calculate the odds ratio for participants' risk of type 2 diabetes given a one standard deviation increase in birthweight. To test for an association between parental diabetes and birthweight, we performed linear regression of self-reported parental diabetes status against birthweight. We performed path and mediation analyses to test the hypothesis that birthweight partly mediates the association between parental diabetes and participant type 2 diabetes status. RESULTS: Of the UK Biobank participants, 277 261 reported their birthweight. Of 257 715 individuals of White ethnicity and singleton pregnancies, 6576 had type 2 diabetes, 19 478 reported maternal diabetes (but not paternal), 20 057 reported paternal diabetes (but not maternal) and 2754 participants reported both parents as having diabetes. Lower birthweight was associated with type 2 diabetes in the UK Biobank participants. A one kilogram increase in birthweight was associated with a lower risk of type 2 diabetes (odds ratio: 0.74; 95% CI: 0.71, 0.76; P = 2 × 10(-57)). Paternal diabetes was associated with lower birthweight (45 g lower; 95% CI: 36, 54; P = 2 × 10(-23)) relative to individuals with no parental diabetes. Maternal diabetes was associated with higher birthweight (59 g increase; 95% CI: 50, 68; P = 3 × 10(-37)). Participants' lower birthweight was a mediator of the association between reported paternal diabetes and participants' type 2 diabetes status, explaining 1.1% of the association, and participants' higher birthweight was a mediator of the association between reported maternal diabetes and participants' type 2 diabetes status, explaining 1.2% of the association. CONCLUSIONS: Data from the UK Biobank provides the strongest evidence by far that paternal diabetes is associated with lower birthweight, whereas maternal diabetes is associated with increased birthweight. Our findings with paternal diabetes are consistent with a role for the same genetic factors influencing foetal growth and type 2 diabetes.ERDF (European Regional Development Fund)ESF (European Social Fund) Convergence Programme for Cornwall and the Isles of ScillyWellcome TrustThe European Research CouncilDiabetes U

Oxygen saturation and perfusion changes during dermatological methylaminolaevulinate photodynamic therapy

Journal ArticleResearch Support, Non-U.S. Gov't"This is the peer reviewed version of the following article: British Journal of Dermatology, Volume 165, Issue 6, pages 1323–1331, December 2011, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011.10554.x/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."BACKGROUND: Methylaminolaevulinate (MAL)-photodynamic therapy (PDT) is a successful topical treatment for a number of (pre)cancerous dermatological conditions. In combination, light of the appropriate wavelength, the photosensitizer protoporphyrin IX (PpIX) and tissue oxygen result in the production of singlet oxygen and reactive oxygen species inducing cell death. OBJECTIVES: This study investigates real-time changes in localized tissue blood oxygen saturation and perfusion in conjunction with PpIX fluorescence monitoring for the first time during dermatological MAL-PDT. METHODS: Oxygen saturation, perfusion and PpIX fluorescence were monitored noninvasively utilizing optical reflectance spectroscopy, laser Doppler perfusion imaging and a fluorescence imaging system, respectively. Patients attending for standard dermatological MAL-PDT were recruited to this ethically approved study and monitored prior to, during and after light irradiation. RESULTS: Significant reductions in mean blood oxygen saturation (P < 0·005) and PpIX fluorescence (P < 0·001) were observed within the first minute of irradiation (4·75 J cm(-2) ) while, in contrast, perfusion was observed to increase significantly (P < 0·01) during treatment. The changes in oxygen saturation and PpIX fluorescence were positively correlated during the initial phase of treatment (r(2) = 0·766). CONCLUSIONS: Rapid reductions in the localized blood oxygen saturation have been observed for the first time to occur clinically within the initial minutes of light irradiation and positively correlate with the concurrent PpIX photobleaching. Furthermore, perfusion increases, suggesting that the microvasculature compensates for the PDT-induced oxygen depletion

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size

Background Obesity is associated with long‐term health consequences including cardiovascular disease. Separating the independent effects of childhood and adulthood obesity on cardiovascular disease risk is challenging as children with obesity typically remain overweight throughout the lifecourse. Methods and Results This study used 2‐sample univariable and multivariable Mendelian randomization to estimate the effect of childhood body size both independently and after accounting for adult body size on 12 endpoints across the cardiovascular disease disease spectrum. Univariable analyses identified strong evidence of a total effect between genetically predicted childhood body size and increased risk of atherosclerosis, atrial fibrillation, coronary artery disease, heart failure, hypertension, myocardial infarction, peripheral artery disease, and varicose veins. However, evidence of a direct effect was weak after accounting for adult body size using multivariable Mendelian randomization, suggesting that childhood body size indirectly increases risk of these 8 disease outcomes via the pathway involving adult body size. Conclusions These findings suggest that the effect of genetically predicted childhood body size on the cardiovascular disease outcomes analyzed in this study are a result of larger body size persisting into adulthood. Further research is necessary to ascertain the critical timepoints where, if ever, the detrimental impact of obesity initiated in early life begins to become immutable